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KMID : 0613820120220121697
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Journal of Life Science
2012 Volume.22 No. 12 p.1697 ~ p.1703
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Improvement of High-fat Diet-induced Obesity by Xanthigen in C57BL/6N Mice
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Choi Kyeong-Mi
Lee Youn-Sun
Kim Won-Kyun
Choi Yung-Hyun
Jung Jae-Chul
Kwak Youn-Gil
Lee Jeong-Rai
Yoo Hwan-Soo
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Abstract
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Obesity is a risk factor for numerous metabolic diseases. Recently, naturally occurring compounds that may improve obesity have received increasing attention. Xanthigen is a mixture of fucoxanthin and punicic acid derived from brown seaweed and pomegranate seed, respectively, which have been traditionally used for lipid-lowering effects in humans. In this study, we investigated whether Xanthigen attenuates high-fat diet-induced obesity in C57BL/6N mice. The mice were fed on a normal diet (ND), high-fat diet (HFD), HFD plus 1% Xanthigen or HFD plus 1% green tea extract (GTE) for 11 weeks. Food efficiency ratio (FER) and body weight were significantly reduced in mice fed HFD plus Xanthigen compared to HFD-fed mice. Consistent with the results in body weight change, Xanthigen also significantly decreased the weights of epididymal adipose tissue, retroperitoneal adipose tissue, and liver in HFD plus 1% Xanthigen-fed mice. The serum level of low-density lipoprotein (LDL)-cholesterol was significantly decreased in HFD plus Xanthigen-fed mice compared to HFD-fed mice. These results suggest that Xanthigen may be useful in the development of a functional health food for anti-obesity.
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KEYWORD
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Xanthigen, C57BL/6N mice, obesity, adipose tissue, LDL-cholesterol
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